Research

Exposure to critical scientific investigation is an integral component of surgical resident education at Henry Ford Hospital. A wide variety of opportunities in basic and clinical research are available for the residents to participate in during surgical residency. All of the surgical residents at Henry Ford Hospital participate in clinical research projects which are presented at local, regional, and national forums. Residents who desire a more broad ranging exposure to research can select a 1 or 2 year funded research fellowship in basic or clinical research. The Department of Surgery at Henry Ford Hospital is a key participant in an NIH Research Training Grant which allows surgical residents to gain additional research training which can lead to an advanced degree (Masters of Science or Ph.D.) A wide variety of research opportunities exist in the department of surgery and health system, however, we have numerous ongoing, research collaborations regionally and nationally to maximize the research experience for our house officers.

Our external research funding approximates $40 million annually, internally supplemented by $15 million from the Fund for Henry Ford Hospital, which places us nationally in the top 15 percent of all such institutions.

 

 


Clinical Research

Clinical research provides state of the art therapeutic regimens for our patients as well as enhancing surgical knowledge. The large, diverse patient base at Henry Ford hospital, combined with the availability of our electronic medical record facilitates clinical research and data acquisition. The majority of faculty in the surgical department are involved in clinical research activities and serve as research mentors for our residents. The departmental research office is staffed by dedicated grants management personnel, clinical research nurses, and clerical staff to aid resident research activities.


Surgical Basic Science Research

A broad range of dedicated, basic science opportunities exist in the department of surgery in the Division of Surgical Research headed by Subhash Gautam Ph.D. Dr. Gautam is a surgical immunologist who is investigating the therapeutic potential of mesenchymal stem cells for compromised wound healing, ischemia-reperfusion injury, and cancer therapeutics. Professor Gautam has a joint appointment with Wayne State University School of medicine in the Department of Immunology/Microbiology and has served as research mentor for numerous graduate students. Promising initial results from these investigations have been presented by our residents at numerous, prestigious surgical meetings including the Surgical Forum and the Society of University Surgeons.

The department of surgery is the only surgical department in the world to participate in  NASA and the National Space Biomedical Research Institute funded medical research involving care capabilities for the current and future space program. This research is crucial for the next phase of space exploration, however, many of the educational and therapeutics techniques which are being developed in these investigations are directly transferable to emergency care on Earth. The NASA research projects involve advanced ultrasound and laparoscopic techniques that astronauts or cosmonauts could use on ther International Space Station; residents who participate in these trials travel to the Johnson Space Center for microgravity experiments in the NASA Microgravity Research Facility.


Basic Funded Science


Advanced Diagnostic Ultrasound in Microgravity
Federal
National Aeronautics & Space Administration (NASA)
PI Scott Dulchavsky, MD, Ph.D.
Minimully Invasive Diagnosis and Therapy of Microgravity Medical Contingencies
Subcontract
Nat’l Space Biomedical Research Institute (NSBRI)
PI Scott Dulchavsky, MD, Ph.D.
Infusion of Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting with Cardiopulmonary Bypass
Clinical Trial
Procter & Gamble Company
PI Robert Brewer, MD
Comparative Study of Ertapenem Sodium vs. Piperacillin/Tazobactam in the Treatment of Complicated Intra-Abdominal Infections
Clinical Trial
Advanced Biologics, LLC
PI Scott Dulchavsky, MD Ph.D.
Comparison of Neutralase during Cardiac Bypass
Clinical Trial

BioMarin
PI/Co-PI Norman A. Silverman, MD

Multi-Center Study to Assess the Safety and Efficacy of Miconazole in Transplant patients
Clinical Trial
Fujisawa USA, Inc.
PI/Co-PI Marwan S. Abouljoud, MD

A Prospective Evaluation of Postopertive Ileus and Acute Opioid Bowel Dysfunction in Patients Undergoing Abdominal Surgery
Clinical Trial
GlaxoSmithKline
PI/Co-PI Chong Suh Lee, MD
Linezolid in the Treatment of Subjects with Noscomial Pneumonia
Clinical Trial
Pfizer, Inc.
PI/Co-PI Pat (Joe) Patton, MD
Efficacy of Human Recombinant Soluble Complement Receptor Type I in Adult women Undergoing Cardiopulmonary Bypass Surgery
Clinical Trial
AVANT Immunotherapeutics, Inc.
PI/Co-PI Norman A. Silverman, MD
Multicenter Trial of Vacuum Assisted Closure Therapy’s in the Treatment and Blinded Evaluation of Open Abdominal Wounds
Clinical Trial
Kinetic Concepts Inc. (KCI)
PI Ilan Rubinfeld, MD
Multicenter Trial of Vacuum Assisted Closure Therapy’s in the Treatment and Blinded Evaluation of Open Chest Wounds
Clinical Trial
Kinetic Concepts Inc. (KCI)
PI Ilan Rubinfeld, MD
Efficacy and Safety of Epoetin Alfa in Critically Ill Subjects
Clinical Trial

Kinetic Concepts Inc. (KCI)
PI H. Matilda Horst
Linezolid in the Treatment of Subjects with Complicated Skin and Soft Tissue Infections
Clinical Trial
Covance Periapproval Services, Inc (Pfizer, Inc)
PI Ann Woodward
Preventing Metabolic Bone Disease After Gastric Bypass
Internal
HFHS
PI Arthur M. Carlin, MD
JWCI Melanoma Multicenter Clinical Trial
Federal
National Institutes of Health/DHHS
PI David Nathansons
Cytokine Gene Therapy of Residual Leukemia
Federal
National Institutes of Cancer/DHHS
PI Subash Gautam, MD
Tissue Culture/Immunochemistry
Federal
National Institutes of Health/DHHS
PI Subash Gautam, MD
Analysis of MSC Interaction with Ischemic Brain Tissue
Federal
National Institutes of Health/DHHS
Co-PI Subash Gautam, MD
Immunological Effects of BMSC's in rates
Contract
Cognate Therapeutics
PI Subash Gautam, MD
Comparison of Clevelox (clevidipine) vs. Nitroglycerin (NTG) for the treatment of hypertension
Clinical Trial
The Medicines Company
PI Norman A. Silverman, MD

 

 

 
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